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Early onset: Brain scans show evidence of Alzheimer’s disease 20 years before symptoms arise (far left), 10 years before (middle), and after the onset of symptoms (right). Beta amyloid, a protein associated with the disease, is more visible in people who develop the disease (top row) than in those who don’t. The more color in the scan, the more beta amyloid is present in the brain.

The first detectable signs of Alzheimer's disease occur as long as a quarter century before symptoms like memory loss become noticeable, according to a detailed chronology of molecular changes to the brain and spinal fluid of people who later developed the brain disease.

The research, published today in the New England Journal of Medicine, provides a timeline of the subtle changes that begin in victims' brains and, importantly, can be detected years ahead of time by MRI exams, blood analyses, or other tests.

To read the full, original article click on this link: Biomarker Roadmap for Alzheimer's Established - Technology Review