Having people ask to "pick your brain" can be the ultimate compliment to an entrepreneur. It makes us feel like we're experts in something, or that we've been successful enough at something that someone values our thoughts. But brain picking comes in many shapes and colors. Some brain pickers (BPs) are just looking for inspiration; talking with you stirs their own ideas. Others want resources--money, contacts, insider knowledge that will help them with their endeavors. None of these are inherently bad, but none of them are good if you aren't getting something out of the sharing.
I used to love it when people asked to pick my brain, especially early into the business. I might not have been drawing a paycheck, but by golly! Someone wanted to talk to me about something. It was a small sign of traction.
The Entrepreneur's Guide to Time Management: How to Pick a Brain Properly, and How to Selectively Allow Yours to Be Picked -- Part I