Results At baseline, 418 participants (10.7%) had cognitive impairment. After a 2-year follow-up, 207 of 3485 initially unimpaired subjects (5.9%) developed incident cognitive impairment. Compared with participants without physical activity, fully adjusted multiple logistic regression analysis showed a significantly reduced risk of incident cognitive impairment after 2 years for participants with moderate or high physical activity at baseline (odds ratio (OR), 0.57; 95% confidence interval (CI), 0.37-0.87 (P = .01); and OR, 0.54; 95% CI, 0.35-0.83 (P = .005); respectively). Further subanalysis including participants (n = 2029) without functional impairment and without prodromal phase of dementia resulted in an even higher reduction of risk of incident cognitive impairment for participants with moderate or high physical activity (OR, 0.44; 95% CI, 0.24-0.83 (P = .01); and OR, 0.46; 95% CI, 0.25-0.85 (P = .01); respectively) compared with no activity.
To read the full, original article click on this link: Arch Intern Med -- Abstract: Physical Activity and Incident Cognitive Impairment in Elderly Persons: The INVADE Study, January 25, 2010, Etgen et al. 170 (2): 186
