In the late 1990s, a handful of physicists and engineers began to take a greater interest in biology. The Human Genome Project was spitting out more and more gene sequences—blueprints for the protein building blocks of the cell—generating a flood of new information about the molecular machinery of life. Trouble was, there were not enough biologists doing the job of figuring out how all these genes and proteins worked together to create a living, breathing organism.
It was around this time that Boston University bioengineer James Collins saw his chance to inject a little engineering know-how into the study of biology. There were two ways to go about it, he figured—either disassemble cells or build them. “A burgeoning young engineer is either the kind of kid who takes stuff apart to try to figure out how it works, or he’s the kid who puts stuff together,” Collins says. Though both approaches seemed promising, there simply wasn’t enough known about the structures or functions of the genes and their protein products to infer how all the parts worked together by taking a cell apart, piece by piece.
To read the full, original article click on this link: Tinkering With Life | The Scientist
